EXPRESS PRECLINA

Preclina has seized the spotlight with EXPRESS PRECLINA, delivering high-quality, accelerated efficacy testing that slashes costs and removes key barriers in the drug development pathway.

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    Compressed
    Timeline

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    Cost
    Cut-down

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    Modular
    Platform

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    Win-Win
    Partnership

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Accelerate your preclinical drug
discovery with Pre-VIVO™ Platform!

With deep clinical expertise in inflammatory skin disorders, Preclina creates custom preclinical models and study plans, providing clear, focused efficacy testing that accelerates your drug development toward IND filing.

  • ATTRACTIVE
    PRICING
  • EXTENDED
    EXPERTISE
  • VERSATILE
    PORTFOLIO
  • RELIABILITY

Customized Psoriasis Efficacy Evaluation to Meet Your Needs

From Market Needs to IND-ready Data, We Build the Bridge for Your
Breakthrough

With Preclina, robust outcomes are achieved with minimal repeated studies, helping our clients secure highly reproducible and statistically powerful results.


No endless repeats, No wasted time!

The data spoke for itself – leading to a successful licensing deal.

  • IMQ-induced Psoriasis
    1. The First Step Toward Successful Drug Development
    2. Unmatched Reproducibility Setting a New Standard that No One Else Can Replicate

  • IL23-induced Psoriasis
    1. Providing Reliable Results
    2. Customized Evaluation Systems Tailored to Client Needs
    3. Fast Track to Clinical Trials

Imiquimod-induced Psoriasis

Psoriasis Induction Model using a TLR Agonist

Our robust and proven model provides a true solution for selecting the right lead candidates, cutting through uncertainty to identify compounds with real clinical potential.

Try our gold-standard model that accurately reflects the IL-23/IL-17 pathway, a key driver of psoriasis.

    1. The Gold Standard Model for Efficacy Evaluation
    2. A Model with High Clinical Translatability
    3. Suitable for Evaluating the Crucial Signaling Cascade in Th17 pathway
    1. Take the Decisive First Step Towards Success with a Reliable Model
    2. High-Quality Testing Services Delivered in the Shortest Timeframe
    3. Solutions to Minimize the Burden of Development

State-of-the-Art Pharmacology Support for Atopic Dermatitis

Step-wise Support for Early Drug Discovery

A full-spectrum, modular platform supporting entire process of drug development, from screening and lead selection to optimization, and providing confirmatory studies through a one-stop service.

Experience customized efficacy testing with stage-matched AD models that accurately replicate disease incidence and severity.

  • Screening Test
    Models
    1. Initial Drug Screening Systems using Hapten-induced Models
    2. Selective Utilization of Stage-specific Mouse Models
    3. Skin Disease Models with Th2 Response

  • Confirmatory Test Models
    1. The Model Best Recapitulating Human Atopic Dermatitis
    2. Definitive Insights from Our HDM-induced AD Model
    3. Decisive Final‑stage Data that Predicts Phase 2 Success

Screening Test Models for Atopic Dermatitis

High Probability of Success through Guided Lead Optimization

Experience Guided Lead Optimization through precise and reproducible in vivo results, maximizing accuracy of SAR analysis.


Our Hapten-Atopy-based Models using genetically predisposed mice offer tailored options for diverse study designs.

  • Oxazolone-induced AD
    1. Premium Preclinical Model for Strategic Lead Optimization
    2. Extensive Experience across Multiple Administration Routes, (Topical Application, SC Injection, Oral Dosing)
    3. High-quality Efficacy Evaluation of Topical Formulations

  • DNCB-induced AD
    1. Systematic DB of Clinical SOC Drug Responses (Steroid, Eucrisa, Dupixent)

      · Your Clinical Benchmark Starts Here !

    2. Customized Hapten Spectrum Tailored to Your Needs (DNCB, DNFB, Oxazolone, MC903)
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Confirmatory Test Models for Atopic Dermatitis

Rational Selection for the Final Stage of Lead Optimization

Validate your lead compounds in a clinically relevant AD model, precisely mirroring human disease triggered by house dust mites.

From efficacy validation to MOA studies, our comprehensive services support scientific verification through advanced immunological parameters.

House Dust Mite-induced AD
    1. Highly Reliable Models with Validated Protocols
    2. Systematic DB of Clinical SOC Drug Responses (Steroid, Eucrisa, Dupixent)

      · Your Clinical Benchmark Starts Here, Too !

    1. Model Creation using Best-quality House Dust Mite Extracts
    2. Precise Recapitulation of Human Atopic Dermatitis
    3. Strongest Clinical Translatability Strategy from the Very First Step of Drug Development

Get in touch with us to find out more
about how we can support you and your research!

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